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Guidelines for Prevention and Control of Occupational Exposure Risks to Cytotoxic Drugs in Medical Institution
- ZHONGGUO YAOFANG Pages: 1-11(2025)
- 作者机构：
1.四川省医学科学院·四川省人民医院/电子科技大学附属医院药学部个体化药物治疗四川省重点实验室，成都 610072
2.电子科技大学医学院，成都 610072
- 作者简介：
- 基金信息：
DOI：
CLC： R95-
Published Online：14 August 2023，
- 稿件说明：
移动端阅览
邹林珂,闫峻峰,刘慧,等.医疗机构细胞毒性药物职业暴露风险防控指南[J].中国药房,
.Guidelines for Prevention and Control of Occupational Exposure Risks to Cytotoxic Drugs in Medical Institution[J].ZHONGGUO YAOFANG,
邹林珂,闫峻峰,刘慧,等.医疗机构细胞毒性药物职业暴露风险防控指南[J].中国药房, DOI：10.6039/j.issn.1001-0408...01.
.Guidelines for Prevention and Control of Occupational Exposure Risks to Cytotoxic Drugs in Medical Institution[J].ZHONGGUO YAOFANG, DOI：10.6039/j.issn.1001-0408...01.
摘要
为医疗机构提供细胞毒性药物职业暴露风险防控策略，提高医务人员的防护意识，降低医务人员发生潜在的职业暴露风险，制定《医疗机构细胞毒性药物职业暴露风险防控指南》。依据世界卫生组织（WHO）指南制定手册方法，收集细胞毒性药物进入医院后的运输、接收、储存、脱包、调剂、成品使用、废物处理7个环节存在的暴露风险问题，采用德尔菲法构建临床问题，采用循证研究方法形成相关证据体后，按照推荐分级的评价、制定与评估（GRADE）方法进行质量评价，并再次通过专家共识法对推荐意见及证据级别达成共识，将工程控制、行政控制和个人防护设备3个不同等级相结合，通过分级管控的方式，最终确定了37个临床问题，共形成36条推荐意见，旨在为医疗机构制定细胞毒性药物分级防控措施提供参考与补充。
Abstract
To provide prevention and control strategies of occupational exposure risks for cytotoxic drugs in medical institutions
improve the awareness of protection among medical staff
and reduce potential occupational exposure risks
the “Guidelines for Occupational Exposure Risk Protection of Cytotoxic Drugs in Medical Institutions” was developed. Based on the World Health Organization (WHO) guidelines development manual
we collected the exposure risk issues in seven stages after the cytotoxic drugs entered the hospital
such as transportation
receipt
storage
unpacking
dispensing
used of finished products
and waste disposal. The Delphi method was used to construct identify clinical issues
and evidence-based research methods were used to develop relevant evidences. Quality evaluation was conducted using the GRADE method
and consensus was reached on the recommendation opinions and evidence levels through expert consensus method. By combining engineering controls
administrative controls and personal protective equipment at different levels
a graded control approach was established. A total of 37 clinical issues were identified
resulting 36 recommendations. This guideline provides reference and supplementation for the formulation of cytotoxic drugs prevention and control measures in medical institutions.
关键词
Keywords
references
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