OBJECTIVE：To evaluate the effect of clinical pharmacists participating in chronic disease management for chronic heart failure （CHF）patients. METHODS ：Totally 160 patients with CHF in our h ospital from Jan. 2016 to Dec. 2017 were divided into intervention group （80 cases）and control group （80 cases）according to random number table method. The patients received CHF routine examination and drug treatment at admission ；on this basis ，the patients in the intervention group received clinical pharmacist chronic disease management as inpatient pharmaceutical care ，medication education at discharge and pharamceutical follow-up at discharge. The cardiac function indexes （NYHA cardiac function classification ，LVEF，NT-proBNP，LVDd）， comprehensive self-care ability （scores of self-care ability ，drug compliance ，understanding of disease-related knowledge ，and total score of comprehensive self-care ability ），and life quality （emotional score ，symptom score ，social restriction score ，and total score of life quality ）at admission ，discharge and 6 months after discharge ；economic indicators （total hospitalization expenses ， hospitalization time ，drug expenses and drug proportion ）during hospitalization ；readmission and case fatality within 6 months after discharge were compared between the two groups. RESULTS ：At admission ，there was no significant difference in the above indicators between 2 groups（P＞0.05）；at discharge ，except for LVEF ，emotional score and social restriction score ，the other indicators in 2 groups were significantly improved ，compared with at admission （P＜0.05）；six months after discharge ，the above indicators of 2 groups were significantly improved compared with at admission ，and LVEF ，LVDd，drug compliance score ，score of understanding of disease-related knowledge ，total score of comprehensive self-care ability ，emotion score ，symptom score ，total score of life quality in the intervention group were significantly better than control group （P＜0.05）. There was no significant difference in the total hospitalization expenses ，hospitalization time ，drug expenses and drug proportion between 2 groups（P＞ 0.05）. Within 6 months after discharge ，the readmission rate of the intervention group was 14.29％，which was significantly lower than that（29.33％）of control group （P＜0.05）. There was no significant difference in case fatality rate between 2 groups（P＞ 0.05）. CONCLUSIONS ：The participation of clinical pharmacists in chronic disease management of CHF patients can significantly improve the cardiac function indexes ，comprehensive self-care ability and quality of life ，and reduce the readmission rate.