OBJECTIVE：To observe the therapeutic efficacy an d safety of rebamipide modified quadruple therapy in the treatment of Helicobacter pylori （HP）positive gastric-ulcer. METHODS ：Totally 150 patients with HP positive gastric-ulcer in our hospital from Mar. 2018 to Mar. 2020 were randomly divided into traditional group and modified group according to random number table ，with 75 cases in each group. Traditional group was given Amoxicillin capsules 1.0 g orally ，twice a day + Clarithromycin tablets 0.5 g orally ，twice a day+ Omeprazole enteric-coated capsules 20 mg orally ，twice a day+Colloidal bismuth pectin capsules 200 mg orally ，twice a day. Modified group was additionally given Rebamipide capsules 0.1 g orally ，3 times a day，Amoxicillin capsule ，Clarithromycin tablet and Omeprazole enteric-coated ca psule（same usage and dosage as traditional group）. Both groups were given medicine for consecutive 8 weeks，and were reexamined 2 weeks after drug withdrawal. After 2 weeks of treatment ，HP eradication rate ，total response rate ，the levels of serum MTL ，CCK，G17，PGⅠ and PG Ⅱ，PGⅠ/Ⅱ were observed in 2 groups. The occurrence of ADR was recorded. RESULTS ：HP eradication rate and total response rate of modified group were significantly higher than traditional group （P＜0.05）. Before treatment ，there was no significant difference in the serum levels of MTL ，CCK，G17，PGⅠ or PG Ⅱ，PGⅠ/PGⅡ between 2 groups（P＞0.05）. After treatment ，the levels of serum CCK ，G17，PG Ⅰ and PG Ⅱ in 2 groups were significantly lower than before treatment ，and modified group was significantly lower than traditional group （P＜0.05）；the serum level of MLT and PG Ⅰ/PGⅡ were significantly higher than before treatment，and modified group was significantly higher than traditional group （P＜0.05）. There was no significant difference in the total incidence of ADR between 2 groups（P＞0.05）. CONCLUSIONS ：Rebamipide modified quadruple therapy can significantly improve therapeutic efficacy and HP eradication rate of HP positive gastric-ulcer patients ，and regulate its ga strointestinal hormone Δ and PG levels with good safety.