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更新时间：2022-06-21

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- China Pharmacy Vol. 32, Issue 16, (2021)
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[J]. China Pharmacy 32(16).(2021)
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[J]. China Pharmacy 32(16).(2021) DOI：

摘要

目的：为多酚化合物在炎症性肠病（IBD）及肠纤维化预防和治疗中的应用提供参考。方法：检索2002年1月－2021年1月发表的相关文献，就多酚化合物对IBD及肠纤维化发生过程中主要信号通路的影响进行综述。结果与结论：多酚化合物防治IBD及肠肠纤维化的作用机制主要是通过调控转化生长因子β1/Smad、磷脂酰肌醇-3激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白、丝裂原活化蛋白激酶等信号通路的活化、信号转导完成的。目前已知的多酚化合物中，姜黄素、黄芩苷、黄蜀葵花总黄酮、异苷草素、绿原酸及白藜芦醇等被证实具有潜在的防治IBD及肠纤维化作用。由于现在缺乏有效的防治手段和相关的临床研究，因此未来仍需进一步开展多酚类活性成分及其药理机制研究，并将其逐步应用到IBD及肠纤维的防治中，为上述疾病临床防治提供新思路。

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结肠炎肠纤维化多酚化合物信号通路研究进展

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Related Author

JIA Suxia

XU Xiaomin

YANG Huicong

LIU Shumin

MENG Jianhua

LIU Rui

PAN Ling

LUO Zhenzhen

Related Institution

Institute of Traditional Chinese Medicine，Heilongjiang University of Chinese Medicine

Graduate School， Guangxi University of Chinese Medicine

Dept. of Pulmonary and Critical Care Medicine，Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine

College of Traditional Chinese Medicine， Tianjin University of Traditional Chinese Medicine

Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine， Peking Union Medical College & Institute of Radiation Medicine， Chinese Academy of Medical Sciences

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