OBJECTIVE：To provide reference for the stable operation of TCM industrial technology innovation strategic alliance（called“TCM industrial alliance ”for short ）as well as the transformation and upgrading of TCM industry. METHODS ： The game theory was adopted to construct the initial game model and repeated game model of cooperative trust among the members of TCM industrial alliance under moral self-discipline ，and mixed strategy game model under external constraints. The main influential factors of trust mechanism construction for TCM industrial alliance were analyzed ，and countermeasures and suggestions were put forward for the trust mechanism construction of TCM industrial alliance in China. RESULTS & CONCLUTIONS ：Both the initial game model and the finite repeated game model showed that the strategy combination of （distrust，distrust）was the only Nash equilibrium. At this time ，the overall benefit of the alliance was the smallest ，and the innovation efficiency and stability of the alliance were very low. The infinite repeated game model showed that the strategy combination of （trust，trust）was the equilibrium path of the repeated game. The long-term benefits of both sides of the game due to trustworthiness were greater than those obtained by dishonesty. At this time ，the total benefits of the alliance were the largest ，but both sides of the game needed to have sufficient patience and enough game times. The mixed strategy game model showed that when the loss of breach of trust was large enough and there was no upper limit ，the alliance members chose to trust each other ，and the strategy of （trust，trust）was the only Nash equilibrium；when the loss of breach of trust was relatively small and closer to the upper limit ，the more reluctant the alliance members were to choose to keep faith ，and the external constraint force was weak. The number of games ，the completeness of game information and the strength of external constraints were the key factors to establish alliance trust mechanism. It is suggested that an efficient communication system ，transparent information disclosure system and perfect reward and punishment system should be established within TCM industrial alliance ，and the role of government and non-governmental third parties should be fully played to promote the stable operation of TCM industrial alliance in China.