OBJECTIVE：To provide reference for the related research and policy-making of drug network transaction governance model. METHODS ：Based on the highly chimerism of agile governance concept and drug network transaction ，the governance dilemma of the existing drug network transaction mode were analyzed ，and the optimization path was refined from the perspectives of governance objectives ，tools and subjects. RESULTS & CONCLUSIONS ：The unique complexity and innovation of drug network transactions had brought many challenges to the regulatory authorities ，which not only manifested that it was difficult to choose governance objectives and governance tools ，but also manifested that the addition of multiple subjects had broken the traditional single supervision mode. In order to further optimize the governance of drug network transactions ，it is necessary to adhere to the concept of agile governance ，intervene in the market with a more positive attitude ，and pursue the balance between safety and efficiency ；respond to risks with more flexible tools ，and achieve the unity of inclusiveness and prudence ；participate in governance with more diversified subjects ，and form a pattern of joint efforts of government ，enterprises and society.