暂无标题

YU Chenchen; ZHANG Chungang; YIN Li; ZHOU Yixuan; CHENG Lan; KANG Tingguo

您当前的位置：

首页 >

文章列表页 >

暂无标题

更新时间：2023-03-01

- 暂无标题
- China Pharmacy Vol. 30, Issue 19, (2019)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2019，
扫描看全文
YU Chenchen, ZHANG Chungang, YIN Li, et al. [J]. China Pharmacy 30(19).(2019)
DOI：

YU Chenchen, ZHANG Chungang, YIN Li, et al. [J]. China Pharmacy 30(19).(2019) DOI：

摘要

目的：考察白藜芦醇/羟丙基-β-环糊精/壳聚糖缓释微球（RES/HP-β-CD/Chitosan）的体外释放度及其在大鼠体内的药动学。方法：采用桨法考察RES原料药、RES/HP-β-CD包合物（RES/HP-β-CD）和RES/HP-β-CD/Chitosan在水中12 h内的体外释放度。比较灌胃给予大鼠RES原料药、RES/HP-β-CD和RES/HP-β-CD/Chitosan后720 min内的药动学特征。结果：与RES原料药比较，RES/HP-β-CD的体外释放度明显增加，120 min的累积释放度为87％；与RES/HP-β-CD比较，RES/HP-β-CD/Chitosan的体外释放明显减缓，释放时间明显延长，12 h的累积释放度为72％。RES原料药、RES/HP-β-CD、RES/HP-β-CD/Chitosan在大鼠体内的药动学参数cmax分别为473.3、2 492.2、590.5 ng/mL，t1/2分别为2.6、0.5、4.6 h，AUC0-12 h分别为514.7、824.6、2 778.5 ng·h/mL。与RES原料药比较，RES/HP-β-CD和RES/HP-β-CD/Chitosan的相对生物利用度分别为172.5％和540.0％。结论：RES/HP-β-CD/Chitosan具有良好的缓释作用，且生物利用度明显高于RES原料药和RES/HP-β-CD。

Abstract

OBJECTIVE： To investigate in vitro release rate and in vivo pharmacokinetics of Resveratrol/hydroxypropyl-β- cyclodextrin/chitosan sustained-release pellets （RES/HP-β-CD/Chitosan） in rats. METHODS： In vitro release rate of RES raw materials， RES-HP-β-CD complexes （RES/HP-β-CD） and RES/HP-β-CD/Chitosan in water within 12 h were investigated by paddle method. The pharmacokinetic characteristics of RES raw materials， RES/HP-β-CD and RES/HP-β-CD/Chitosan were compared within 720 min after intragastric administration. RESULTS： Compared with RES raw materials， in vitro release rate of RES/HP-β-CD was increased significantly， and 120 min accumulative release rate reached 87％. Compared with RES/HP-β-CD， in vitro release rate of RES/HP-β-CD/Chitosan were relieved significantly； release time prolonged significantly； 12 h accumulative release rate was 72％. The pharmacokinetic parameters of RES raw materials， RES/HP-β-CD and RES/HP-β-CD/Chitosan included that cmax were 473.3， 2 492.2， 590.5 ng/mL； t1/2 were 2.6， 0.5， 4.6 h； AUC0-12 h were 514.7， 824.6， 2 778.5 ng·h/mL. Compared with RES raw materials， relative bioavailability of RES/HP-β-CD and RES/HP-β-CD/Chitosan were 172.5％ and 540.0％. CONCLUSIONS： RES/HP-β-CD/Chitosan shows good sustained-release effect， and its bioavailability is significantly higher than that of RES raw materials， RES/HP-β-CD.

关键词

白藜芦醇羟丙基-β-环糊精壳聚糖释放度药动学大鼠

Keywords

ResveratrolHydroxypropyl-β-cyclodextrinchitosanRelease ratePharmacokineticsRats

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

白藜芦醇-羟丙基-β-环糊精-壳聚糖缓释微球的制备及表征

五酯软胶囊对西罗莫司在大鼠体内药动学的影响

黄芩苷前体脂质体的制备及其在大鼠体内的药动学研究

吴茱萸碱脂质体在大鼠体内的药动学及小鼠体内的组织分布研究

前列安颗粒中芍药苷和连翘苷在大鼠体内的药动学研究

Related Author

HAN Lan

XU Wen

LIU Tao

FU Xiaoyue

CAO Zhihong

MA Min

SUI Zhongguo

JIN Yaxiang

Related Institution

Dept. of Pharmacy， the Third Affiliated Hospital of Anhui Medical University

College of Pharmacy， Anhui Medical University

Department of Cardiology,Affiliated Hospital of Southwest Medical University

Address：8/F,129 Daping Main Street,Yuzhong District,Chongqing 400042,P.R.China
Technical support is provided by Beijing Founder Electronics co., LTD 渝ICP备15012710号公网安备50010302001817
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰

暂无标题

DOI：

摘要

Abstract

关键词

Keywords

references