OBJECTIVE： To mine the prescription rule of set prescription preparation containing Atractylodes macrocephala， and to provide reference for modern clinical application of A. macrocephala and R&D of related new drugs. METHODS： All set prescription preparations containing A. macrocephala were collected from Medicine Standard of Ministry of Health of the people’s Republic of China·TCM Set Prescription Preparation （called TCM Set Prescription Preparation for short）. The prescription medication， functions and other information were included into Traditional Chinese Medicine Inheritance Support Platform （V2.5）. The frequency of attending syndromes and attending diseases were analyzed by using the correlation rule of software. The prescription rules of high frequency attending syndromes and diseases were analyzed. RESULTS： There were a total of 561 set prescription preparations containing A. macrocephala， 118 attending syndromes and 140 attending diseases. Among them， high frequency syndromes were syndrome of deficiency of both qi and blood， syndrome of deficiency of spleen qi and stomach qi. Their high frequency medicine combinations were modified Bazhen tang and Sijunzi tang. High frequency attending diseases were diarrhea and menstruation disorders. Medicine combination for diarrhea was based on Yigong san， including Liujunzi tang and Xiangsha liujunzi tang. Medicine combinations for menstruation disorders were based on Bazhen tang， including Guishao liujunzi tang， Shiquan dabu tang， Bazhen yimu pills and Xiangfu pills.  CONCLUSIONS： The study objectively shows attending syndromes and the prescription rules of set prescription preparations containing A. macrocephala through big data. The study also provides reference for the clinical application and related R&D of A. macrocephala.