OBJECTIVE： To analyze the characteristics of new ADR in psychiatric hospital， and to provide reference for rational use of psychiatric drugs in clinic. METHODS： Totally 115 cases of new ADR reported to National ADR Monitoring Center by Beijing Anding Hospital of Capital Medical University from Jan. 2010 to Dec. 2017 were analyzed retrospectively. The patient’s gender， age， route of administration， dosage form， drug type， organ or system involved in ADR， main manifestations， top 5 drugs that caused the most ADR， incubation period and outcome of ADR were analyzed statistically. RESULTS： Among 115 cases of new ADR， the incidence of female （59 cases） was slightly higher than that of male （56 cases）. Patients mainly aged 21-30 years old （32 cases， 27.83％）. There were 102 cases of ADR induced by oral administration （88.70％）， among which there were 76 cases （74.51％） of ADR induced by common tablet （oral administration）. The drug type involved was mainly antipsychotics （66 cases， 57.39％）. Nervous system was the most common involved system （19 cases， 15.45％）. Top 5 drugs that caused the most ADR were olanzapine （19 cases， 15.45％）， quetiapine （17 cases， 13.82％）， lithium carbonate （9 cases， 7.32％）， risperidone （7 cases， 5.69％） and sodium valproate （6 cases， 4.88％）. Olanzapine could cause the increase of adrenocorticotropin and oculomotor crisis； quetiapine could cause nasal bleeding， oculomotor crisis，etc. ADR mainly occurred within one month of medication （93 cases， 80.87％）. Among 115 cases of ADR， there were 108 cases of general ADR （93.91％） and 7 cases of severe ADR （6.09％）. All disease cases received treatment or immediate withdrawal without fatal case. CONCLUSIONS： In the process of clinical service， clinical pharmacists should assist doctors to strengthen new ADR monitoring in psychiatric department， and use psychiatric drugs reasonably. In addition， national drug regulatory authorities should improve the instructions of psychiatric drugs constantly， which can promote safe use of drugs effectively.