OBJECTIVE： To explore the situation and research hotspots of drug centralized procurement study， and to find existing problems in the development of this field so as to provide reference for further improving drug centralized procurement in China. METHODS： The literatures were retrieved from CNKI， Wanfang and VIP database during 2000-Jun. 2018. CiteSpace software， which was a visualization software， was used to analyze statistically the publication time， author， research institution and keywords. RESULTS： A total of 3 455 literatures were included in the study. The number of literatures in this field had increased significantly since 2009. The author and institution cooperation network were scattered relatively. The research teams were mainly universities and research institutes， few of which were public hospitals. Before 2009，the scholars focused on feasibility analysis of the implementation of drug centralized procurement policy in China， analysis of centralized drug procurement system and model introduction. After New Medical Reform in 2009， great importance was attached to effect evaluation of essential medicine centralized procurement and rational drug use in public hospital. In recent year， the latest outbreak of the keywords were “drug pricing reform”“price negotiation”“medical insurance payment”“drug shortage”“tripartite linkage of medical institutions”“drug purchasing with quantity”“supply guarantee” and so on， which were the newest research hotspots.  CONCLUSIONS： The research focus of drug centralized procurement is changing with the adjustment of national policy. At present， the focus of research in this field has shifted to the research on the mode and situation of drug purchasing with quantity， the reform of medical insurance payment standard， the negotiation of drug price in public hospitals and the reform of drug price. Under the background of “Tripartite Linkage of Medical Institutions”， the strategy of drug supply guarantee system was improved， and the countermeasures are explored to alleviate drug shortage and irrational drug use. In the future， cooperation and academic exchanges should be strengthened in this field so as to make the multi-center and multi-disciplinary cooperation mode should become the mainstream. At the same time， public hospitals should enhance their main position and actively participate in research on related topics， so as to promote to establish and improve the drug supply guarantee system and reduce the medical burden of the public.