OBJECTIVE： To provide reference for rational use of edible and medicinal TCM in life and the clinic by analyzing the literatures about ADR induced by edible and medicinal TCM. METHODS： Based on 101 kinds of edible and medicinal TCM issued by National Health and Family Planning Commission in 2014， relevant literatures were retrieved from CNKI， Wanfang database and VIP during database establishment and Dec. 2017. The information （gender， age， allergic history） of patients， types and amounts of edible and medicinal TCM-induced ADR， first occurrence time， organ or system involved， clinical manifestations， severe ADR， form of drug use were collected and analyzed statistically. RESULTS： A total of 515 literatures were collected； among 101 kinds of edible and medicinal TCM， 46 kinds of TCM caused ADR in 1 707 cases. There were 817 male cases and 767 female cases， involving 123 unknown cases. The age of them mostly ranged 0-19 years old （865 cases， 50.67％）. There were 1 275 unknown allergic cases， accounting for 74.69％. Among 46 kinds of TCM， Ginkgo biloba （595 cases， 34.86％） and Houttuynia cordata （512 cases， 29.99％） caused more cases of ADR. There were 615 cases of normal dose （36.03％） and 436 cases of excessive dose （25.54％）； the rest was unknown. ADR occurred in 1 201 cases within 24 h after medication （70.36％）. ADR induced by edible and medicinal TCM involved all systems of the body. The main clinical manifestations were gastrointestinal damage， nervous system damage， systemic damage， skin and its appendents damage and respiratory system damage. Most of severe ADR cases were caused by Salisburia adiantifolia （453 cases/595 cases， cases number of severe ADR/case number of ADR， similarly hereinafter）， H. cordata （105 cases/512 cases）， Cannabis sativa （94 cases/170 cases） and Crataegus pinnatifida （85 cases/118 cases）. ADR occurred in 933 cases after using in form of food； 725 cases of ADR occurred after using in form of medicine； 49 cases of ADR occurred after contacting. Among 725 ADR cases during medicinal use， 441 cases were caused by single medicine （60.83％）； main dosage form of ADR was injection （517 cases， 71.31％）. CONCLUSIONS： Teenagers are susceptible population of ADR induced by edible and medicinal TCM. G. biloba and H. cordata are common drugs that cause ADR. Both normal dosage and overdose may lead to the occurrence of ADR； most of ADR occurs within 24 h after medication； there are various clinical manifestations. Edible use， medicinal use and even contact may cause ADR； single medicine and combination easily cause ADR； main dosage form of ADR is injection. Clinicians and pharmacists should pay attention to ADR induced by food/medicine.