OBJECTIVE： To explore a new management mode of drug dispensing departments. METHODS： To integration the drug dispensing departments in our hospital， the original 4 pharmacies were integrated into 2 dispensing centers of outpatient department and inpatient department， the management measures were formulated and implemented， such as changing the content of drug dispensing center service， changing drug distribution pathway， setting up accounting pharmacist and prescription pharmacist position， implementing comprehensive drug delivery. The management of drug dispensing departments was optimized with PDCA cycle management. The work efficiency， inventory turnover sum， coverage rate of prescription checking， prescription pass rate and drug delivery rate were collected， analyzed and counted before （Dec. 2017-Feb. 2018） and after integration and PDCA cycle management （Mar. 2018-May 2018）. The internal evaluation and external evaluation were conducted by sampling survey so as to evaluate the effects of management mode. RESULTS： After integration and PDCA cycle management in pharmacy department of our hospital， work efficiency of drug dispensing department increased by 20.4％； inventory turnover sums decreased by 37.6％； the coverage rate of prescription checking reached 85.7％； The rate of qualified prescription reached 94.3％， delivery rate reached 97.8％. The proportion of rational integration by internal evaluation and external evaluation were 95％ and 93％. CONCLUSIONS： After integration， drug dispensing department establish new management mode and improve pharmaceutical care.