OBJECTIVE： To evaluate the effects of clinical pharmacist-led chronic disease management on the improvement of drug understanding in elderly hypertensive patients. METHODS： In designed randomized controlled study， elderly hypertensive patients met inclusion criteria were randomly divided into control group and intervention group at discharge； clinical pharmacists followed up two groups during different periods. Intervention group was followed up once every 2 weeks in the first 3 months and once every 4 weeks in the latter 3 months. Control group was followed up once every 3 months， lasting for 6 months. The times of drug reorganization， medication education， ADR education， lifestyle education and patient counseling were counted in 2 groups during follow-up period. The drug understanding of patients was scored in 2 groups at 3 and 6 months （1-3 points， 1 point was complete understanding， 3 points meant no understanding）. RESULTS： Finally， 32 and 25 patients were included in control group and intervention group， there was no statistical significance in baseline characteristics and the score of drug understanding [（1.59±0.49）， （1.6±0.5）] between 2 groups （P＞0.05）. In control group and intervention group， at 3 months， the times of drug reorganization were （0.34±0.65） and （2.48±2.43） （P＜0.05）； those of medication education were （1.56±2.23） and （2.08±2.80）； those of ADR education were （0.66±1.07） and （4.44±3.01） （P＜0.05）； those of lifestyle education were （0.38±0.66） and （2.64±2.83） （P＜0.05）； those of patient counseling were （0.41±1.10） and （0.44±0.92）； those of score of drug understanding were （2.00±0.67） and （1.32±0.56）， respectively （P＜0.05）. At 6 months， above 6 indexes of 2 groups were （0.09±0.39） and （1.88±1.76）（P＜0.05）， （0.09±0.39） and （1.40±2.10）（P＜0.05）， （0.13±0.42） and （1.76±1.56）（P＜0.05），（0.03±0.18） and （0.36±0.81）（P＜0.05），（0.06±0.35） and （0.16±0.47）， （1.97±0.74） and （1.16±0.37），（P＜0.05）. For the items of the drug understanding， the intervention group was significantly better than control group. CONCLUSIONS： Clinic pharmacist-led chronic disease management can improve the drug understanding of elderly hypertensive patients.