OBJECTIVE： To study the protective effects of Miao medicine Liqi huoxue dropping pills on chronic heart failure （CHF） model rats. METHODS： Totally 60 SD rats were randomly divided into normal group （10 rats） and modeling group （50 rats）. Modeling group was given subcutaneous injection of isoproterenol （ISO） to induce CHF model. After modeling， CHF model rats were randomly divided into model group， enalapril group （positive control， 20 mg/kg） and Liqi huoxue dripping pills low-dose， medium-dose and high-dose groups （43.75， 87.50， 175.00 mg/kg）， with 10 rats in each group. Administration groups were given relevant medicine intragastrically once a day； normal group and modeling group were both given constant volume of normal saline intragastrically. After 4 weeks of administration， the cardiac function indexes （LVSP， LVEDP， +dp/dtmax， －dp/dtmax） of rats were monitored. The left ventricular mass index was calculated. The morphologic changes of myocardial tissue were observed by HE staining. The myocardial fibrosis was observed by Masson staining， and CVF was calculated. The serum contents of BNP， TNF-α and IL-6 were detected by ELISA. RESULTS： Compared with normal group， there was severe myocardial tissue injury of rats and the degree of myocardial fibrosis increased significantly in model group； the levels of LVSP and ±dp/dtmax were decreased significantly， while LVEDP， left ventricular mass index， CVF， serum contents of BNP， TNF-α and IL-6 were increased significantly （P＜0.05 or P＜0.01）. Compared with model group， myocardial tissue injury and the degree of myocardial fibrosis were relieved significantly in enalapril group and Liqi huoxue dripping pills medium-dose and high-dose groups； while the levels of LVSP and ±dp/dtmax were increased significantly； LVEDP， left ventricular mass index， CVF， serum contents of BNP， TNF-α and IL-6 were decreased significantly （P＜0.05 or P＜0.01）. CONCLUSIONS： Liqi huoxue dripping pills can protect ISO-induced CHF model rats， improve cardiac function indexes， relieve myocardial tissue injury and the degree of myocardial fibrosis and reduce the serum contents of BNP， TNF-α and IL-6.