OBJECTIVE： To provide reference for strengthening the management and control of adjuvant drug， and improving the rational drug use. METHODS： The management measures of adjuvant drug in our hospital were introduced. A concept of “adjuvant drug use density” was introduced to assessment management， and then relevant data of our hospital was collected before and after the implementation of adjuvant drug management. The effects of management were evaluated using drug proportion， adjuvant drug use density and cost of adjuvant drug as indexes. RESULTS： The significant achievement in our hospital was obtained through technological and administrative intervention as strengthening adjuvant drug management， the quantitative index， group assessment， monitoring and early warning， drug withdrawal due to out of limit， limited purchasing， physician training. The cost of adjuvant drug were 1 943.92 ten thousand yuan in May 2016 （the beginning of management and control） and 540.57 ten thousand yuan in Jun. 2017. The drug ratios were 39.90％ and 33.76％. Compared with before management， the decline proportion of adjuvant drug use density reached 12.86％-86.32％ after management. The number of irrational drug use case decreased from 639 cases （among 535 medical cases） to 147 cases （among 538 medical cases）. CONCLUSIONS： The adjuvant drug management and control of our hospital can not only reduce adjuvant drug expense and drug occupation ratio， but also enhance the rational drug use. Nevertheless， there are some difficulties yet on account of lacking of occupation policies and criteria.