OBJECTIVE： To establish a method for simultaneous determination of 12 kinds of microelements in Yizhong shengxue tablets. METHODS： ICP-MS method was adopted. Rf power was set at 1 350 W； plasma gas velocity was 15.0 L/min and carrier gas velocity was 1.12 L/min； the oxide index （CeO+/Ce） was less than 0.5％， and the double charge index （Ba2+/Ba+） was less than 1％； the integration time was 0.1 s， high salt atomizer was used， which atomizing chamber temperature was 2 ℃； repetition times was 3 times； the peristaltic pump frequency was 0.1 rps and the sampling depth was 7.0 mm. The microware digestion power was 3 600 W and the heating process was heated to 190 ℃ maintaining for 48 h， and then cooled to room temperature， finally heated to 150 ℃ maintaining for 12 h. RESULTS： The linear range of B， V， Cr， Mn， Co， Ni， Cu， Zn， Se， Rb， Mo and Sn were 0.05-150 μg/L（r＝0.999 8）， 0.05-150 μg/L （r＝0.999 7）， 0.05-150 μg/L（r＝0.999 5）， 0.05-150 μg/L（r＝0.999 6）， 0.05-150 μg/L （r＝0.999 7）， 0.05-150 μg/L （r＝0.999 8）， 0.05-150 μg/L （r＝0.999 6）， 0.05-150 μg/L （r＝0.999 8）， 0.05-150 μg/L （r＝0.999 5）， 0.05-150 μg/L （r＝0.999 9）， 0.05-150 μg/L （r＝0.999 6）， 0.05-150 μg/L （r＝0.999 7）， respectively. The limits of quantitation were 0.017， 0.007， 0.021， 0.042， 0.013， 0.017， 0.018， 0.019， 0.020， 0.011， 0.011， 0.018 μg/L； the limits of detection were 0.005， 0.002， 0.007， 0.011， 0.003， 0.005， 0.004， 0.004， 0.006， 0.003， 0.003， 0.005 μg/L， respectively. RSDs of precision， stability and reproducibility tests were all lower than 6％. The recoveries were 95.138％-104.928％ （RSDs were 0.96％-2.97％， n＝9）. Average contents of 12 kinds of microelements were 5.266， 0.453， 1.581， 170.600， 11.280， 5.204， 1.560， 24.300， 0.987， 7.302， 0.239 and 0.702 μg/g. CONCLUSIONS： Established method is rapid， sensitive and accurate for simultaneous determination of 12 kinds of microelements in Yizhong shengxue tablets. The contents of Mn

Zn

Co

Rb and B in Yizhong shengxue tablets were relatively high.