OBJECTIVE： To evaluate the risk factors for intravenous dripping of vancomycin-induced acute kidney injury （AKI） in Chinese patients. METHODS： The case-control studies about risk factors for intravenous dripping of vancomycin-induced AKI were retrieved from PubMed， Embase， Cochrane library， CNKI， VIP， CBM and Wanfang database during database establishment to Dec. 2017. The data of included literatures was extracted. After quality evaluation was carried out with Newcastle Ottawa quality assessment scale， Meta-analysis was conducted by using RevMan 5.2 software. RESULTS： A total of 11 studies were included， involving 1 378 patients. 20 risk factors were involved， 11 of which were significantly different （P＜0.05）. General information of patients included low body weight [MD＝－2.19，95％CI（－4.03，－0.35），P＝0.020]， intensive care unit （ICU） admission [OR＝2.52，95％CI（1.33，4.78），P＝0.005]， low creatinine clearance rate [MD＝－17.43，95％CI（－20.76，－14.10），P＜0.001]， high acute physiological and chronic health score Ⅱ（APACHE-Ⅱ）score [MD＝4.13，95％CI（2.44，5.82），P＜0.001]； combined primary diseases included respiratory failure [OR＝4.07， 95％CI＝2.59，6.40， P＜0.001] and severe cardiovascular disease [OR=2.01，95％CI（1.34，3.02）， P＝0.007]； drug combination included diuretic [OR＝2.97， 95％CI （2.15， 4.11）， P＜0.001]， vasopressor agent [OR＝4.48，95％CI（2.63，7.62），P＜0.001] and ACEI or ARB [OR＝1.84，95％CI（1.17，2.90）， P＝0.009]； vancomycin use included long medication time [MD＝2.03， 95％CI （0.90，3.15）， P＝0.004] and high trough concentration [MD＝8.11，95％CI（5.38，10.85）， P＜0.001]. CONCLUSIONS： Low body weight， ICU admission， low creatinine clearance rate， high APACHE-Ⅱ score， respiratory failure， combined with diuretics or vasopressors agent， long medication time and high trough concentration are the risk factors for vancomycin- induced AKI.