OBJECTIVE： To establish a method for simultaneous determination of 10 active components （albiflorin， paeoniflorin， β-ecdysterone， liquiritin， ferulic acid， liquiritigenin， cinnamic acid， cinnamaldehyde， paeonol and ammonium glycyrrhetate） in Wenjing decoction. METHODS： HPLC method was adopted. The determination was performed on Kromasil C18 column with mobile phase consisted of acetonitrile-0.1％ phosphoric acid water solution （gradient elution） at the flow rate of 1.0 mL/min， in dual wavelength switching detection （0-25 min， 240 nm for albiflorin， paeoniflorin， β-ecdysterone， liquiritin， ferulic acid； 25-65 min， 275 nm for liquiritigenin， cinnamic acid， cinnamaldehyde， paeonol， ammonium glycyrrhetate）. The column temperature was set at 25 ℃， and sample size was 20 μL. RESULTS： The linear range of albiflorin， paeoniflorin， β-ecdysterone， liquiritin， ferulic acid， liquiritigenin， cinnamic acid， cinnamaldehyde， paeonol and ammonium glycyrrhetate were 4.04-80.80， 19.32-368.40， 2.62-52.40， 17.52-350.40， 2.07-41.40， 4.02-80.40， 0.56-11.20， 1.69-33.80， 2.18-43.60 and 72.10-1 442.00 μg/mL （all r≥0.999 6）， respectively. The limits of detection were 0.06， 0.03， 0.04， 0.06， 0.07， 0.05， 0.04， 0.06， 0.07， 0.09 μg/mL， respectively. The limits of quantitation were 0.17， 0.09， 0.13， 0.19， 0.20， 0.18， 0.11， 0.15， 0.18， 0.25 μg/mL， respectively. RSDs of precision， reproducibility and stability tests （24 h） were all lower than 3.5％ （n＝6-7）. The average recovery rates were 97.72％-100.60％ with the RSDs of 0.80％-2.49％ （n＝6）. CONCLUSIONS： The established HPLC method is accurate， reliable and specfic， and suitable for simultaneous determination of 10 active components as albiflorin in Wenjing decoction.