OBJECTIVE： To establish the quality standard of Chailing hugan granules. METHODS： TLC was used for qualitative identification of Radix bupleuri， Atractylodes macrocephala and Glycyrrhiza uralensis. The content of total flavonoids （by rutin） in preparation was determined by UV-visible spectrophotometry. The moisture， dissolubility and granularity of preparation were determined. RESULTS： TLC spots of R. bupleuri， A. macrocephala and G. uralensis were clear and well-separated without interference from negative control. The linear range of rutin was 0.050-0.300 mg/mL （r＝0.999 8）. RSDs of precision， stability and reproducibility tests were all lower than 2％. The recoveries were 97.89％-100.01％ （RSD＝0.68％， n＝9）. The content of samples were 1.920-2.018 mg/g. The contents of moisture in 3 batches of samples were 1.54％， 1.62％ and 1.57％； all samples dissolved within 5 min. The sum of granules not passing through No.1 sieve and passing through No.5 sieve were 2.13％， 2.51％， 2.38％， which were all in line with the requirements of Chinese Pharmacopeia （2015 edition，Vol Ⅳ）. CONCLUSIONS： The content of total flavonoicle in Chailing hugan granules should be no less than 1.57 mg/g （by rutin）. Established quality standard is simple， rapid， accurate and reproducible， and can be used for quality control of Chailing hugan granules.