OBJECTIVE： To study the effects of emodin combined with baicalin on acute pancreatitis （AP） model rats and its possible mechanism. METHODS： A total of 70 rats were randomly divided into sham operation group， model group， emodin group （250 mg/kg）， baicalin group （250 mg/kg）， octreotide group （positive control， 10 μg/kg）， N-acetyl cysteine group （positive control， 180 mg/kg）， emodin+baicalin group （125 mg/kg emodin+125 mg/kg baicalin）， with 10 rats in each group. Except for sham operation group， AP model was induced in each group. After modeling， relevant medicines were given intravenously. After 3， 6， 12， 24 h of medication， the serum levels of amylase and lipase were determined. After 24 h medication， serum levels of SOD， MDA， GSH， MPO and level of Caspase-3 in pancreatic tissue were determined. The levels of Akt phosphorylation and expression of Nrf2 protein in pancreatic tissue of rats were determined by Western blot assay. Another 40 ratss were randomly divided into sham operatsion group， model group， emodin+baicalin group （125 mg/kg emodin+125 mg/kg baicalin） and emodin+baicalin+LY294002 （Akt specific inhibitor） group （125 mg/kg emedin+125 mg/kg baicalin+100 mg/kg LY294002）， with 10 ratss in each group. Mechanism verification test was performed. The modeling and medication method of those groups were same to above groups， 24 h later. The level of Akt phosphorylation and the expression of Nrf2 protein were determined in pancreatic tissue of rats. RESULTS： Compared with sham operation group， the serum levels of amylase， lipase of rats were significuntly increased in model group after 3 h of medication （P＜0.01）； levels of MDA， MPO in serum and Caspase-3 in pancreatic tissue were significantly increased in model group （P＜0.01）， while the levels of SOD， GSH in serum and the levels of Akt phosphorylation and the expression of Nrf2 protein were decreased significantly in pancreatic tissue of rats（P＜0.01）. Compared with model group， the serum levels of amylase and lipase were decreased significantly in administration groups after 6 h of medication （P＜0.01）. After 24 h medication， the levels of MDA， MPO in serum and Caspase-3 in pancreatic tissue were decreased significantly （P＜0.01）， while the levels of SOD， GSH in serum and the levels of Akt phosphorylation and the expression of Nrf2 protein were increased significantly in pancreatic tissue of rats （P＜0.01）. In mechanism verification test， compared with emodin+baicalin group， the levels of Akt phosphorylation and the expression of Nrf2 protein in pancreatic tissue were decreased significantly in emodin+baicalin+LY294002 group （P＜0.01）. CONCLUSIONS： Emodin combined with baicalin shows certain improvement effect on AP rats， the mechanism is that the level of Akt phosphorylation is promoted so as to up-regulate the expression of Nrf2 protein， and the expression of antioxidant enzyme is promoted so as to reduce the level of oxidative stress in AP model rats.