OBJECTIVE： To prepare Niflumic acid colon-targeted delivery beads， and to evaluate in vitro drug release. METHODS： Niflumic acid-loaded nanomicelles were prepared with D-α-tocopheryl polyethylene glycol 1000 succinate （TPGS1000） as carrier material. Entrapment efficiency， drug-loading amount， particle size， Zeta potential and polydispersity coefficient （PDI） of Niflumic acid-loaded nanomicelles was investigated. The nanomicelles were encapsulated into pectin by using piercing-solidifying method to form Niflumic acid colon-targeted delivery beads. The morphology of Niflumic acid colon-targeted delivery beads was observed， and particle size and span was calculated. The drug release of Niflumic acid-loaded nanomicelles and Niflumic acid colon-targeted delivery beads in artificial gastric juice （2 h）， artificial intestinal fluid （3 h） and artificial colon fluid （3 h） were compared. RESULTS： The encapsulation efficiency of Niflumic acid-loaded nanomicelles was （93.42±2.33）％， drug-loading amount was （8.54±0.36）％； particle size was （25.8±0.6） nm （n＝3）； Zeta potential was （－18.73±0.23） mV （n＝20）； PDI was 0.25. Niflumic acid colon-targeted delivery beads were round in appearance and rough in texture； the particle size was （1.33±0.14） mm （n＝3） and span was 0.26. Accumulative release rate of Niflumic acid-loaded nanomicelles was more than 60％ within first 5 h. Accumulative release rate of Niflumic acid colon-targeted delivery beads was lower than 30％ within first 5 h， and accumulative release rate were both higher than 80％ in 8 h. CONCLUSIONS： The preparation method is simple and reliable.  Niflumic acid colon-targeted delivery beads are prepared successfully.