OBJECTIVE： To adopt SIMPLE pharmaceutical care mode in chronic disease management of bronchial asthma and COPD patients， and to evaluateits the effect. METHODS： By random sampling， a total of 200 bronchial asthma and COPD patients selected from respiration department in the First Affiliated Hospital of Soochow University during Sept. 2016-Jun. 2017 were divided into control group （100 cases） and  intervention group （100 cases） by simple randomization. Control group received routine treatment. Intervention group additionally received education on quitting smoking， effective use of the inhaler， monitoring detection indexes， selecting drugs correctly， scientific life style. Inhaled device scores， lung function indexes （FEV1％， FEV1/FVC）， the number of  patients with acute attack/exacerbation， clinical effective control rates， ADR occurrence rates， compliance of using apparatus （MMAS-8 score）were compared between 2 groups before enrollment， 3 and 6 months after enrollment. RESULTS： Commpared with during enrollment， inhaled device score， clinical effective control rate and MMAS-8 score of intervention group incereased significantly 3，6 months after enrollment， while patients with acute attack/exacerbation ≥2 times decreased significantly， with statistical significance （P＜0.05）. Compared with control group， inhaled device score， clinical effective control rate， MMAS-8 score  and FEV1％ of intervention group increased significantly， patients with acute attack/exacerbation ≥2 times decreased significantly 3 and 6 months after enrollment with statistical significance （P＜0.05）； the ADR occurrence rate was lower than control group，with statistical significance（P＜0.05）. CONCLUSIONS： Chronic disease management of bronchial asthma and COPD patients with SIMPLE pharmaceutical care mode can improve medication compliance and clinical efficacy， and reduce ADR.