OBJECTIVE: To reduce the occurrence of ADR induced by nutrition support drugs in tumor patients, and to improve survival quality. METHODS: Through National ADR Monitoring System, the information of tumor patients with ADR induced by nutrition support drugs (amino acid, fat emulsion, electrolyte, vitamin and so on) were collected from our hospital during 2014-2016. Age, body weight, ADR severity, gender, route of administration, type of tumor, type of nutrition support drugs, organs/systems/functions involved in ADR, outcome, occurrence of time of ADR were all analyzed. Spearman rank correlation analysis or χ2 test was adopted for correlation analysis of severity degree, occurrence time and factors ADR outcome. RESULTS: Totally 163 ADR cases were collected. Age of patients was (52±13) years old, and body weight was (50±23) kg. There were 136 general ADR and 27 severe ADR. ADR cases were mostly female case (108 cases), intravenous dripping (152 cases), reproductive system tumor (43 cases) and Amino acid injection (62 cases). Organs/systems/functions involved in ADR included systemic reaction (47 case time), digestive system (44 case time), circulatory system (41 case time), skin and its appendants (32 case time) and nervous system (16 case time). 79 patients were cured; 118 ADR cases occurred within 24 h after medication, and 45 ADR cases occurred more than 24 h after medication. 27 patients with severe ADR were given relevant medicine intravenously, and 17 ADR cases occurred with 24 h. However, no risk factors were found related to the severity degree of ADR (P>0.05). Age (P=0.005), gender (P=0.001), types of tumer (P<0.001) were correlated with the occurrence time of ADR. Body weight (P=0.036), gender (P=0.041), administration route (P=0.028) were correlated with ADR outcome. CONCLUSIONS: Medical staff should pay attention to ADR induced by nutrition support drugs, early prevention, close monitoring and timely management so as to reduce the occurrence of ADR and improve survival quality.
关键词
营养支持类药物肿瘤患者不良反应关联性分析
Keywords
Nutrition support drugsTumor patientsADRCorrelation analysis
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Related Author
WU Yanyan
WANG Can
YANG Xinwei
KONG Wenqiang
HU Xuelian
LIAO Jingping
YU Xiquan
SONG Hongtao
Related Institution
Dept. of Pharmacy, Second Affiliated Hospital, Army Medical University
Dept. of Pharmacy, Chongqing Health Center for Women and Children/Women and Children’s Hospital of Chongqing Medical University