OBJECTIVE： To promote the realization of information management for hospital pharmacy. METHODS： The practice of pharmacy information management pathway in our hospital was introduced in respects of drug supply， rational drug use monitoring， pharmacy information dissemination， etc. The effects of information management were evaluated in respects of work efficiency， the rate of drug dispensing error and rational drug use index， etc. RESULTS： The information management pathway of our hospital included drug purchase， warehousing and keeping system， drug distribution management system， reasonable drug use monitoring information module， etc. It realized automatic generation and issue of purchase plan， acceptance bar code of drug warehousing， real-time drug stocking and location changing， drug guarantee delivery in advance， window drug delivery and check barcode scanning， drug distribution quality information management， whole process temperature and humidity monitoring， unreasonable prescription after the event， in the event， in advance， early warning of drug use， real-time monitoring of drug use and administration of drugs for chronic diseases， etc. After the implementation of information management， the time of drug warehousing invoice input and drug stocking were shortened. Among drug dispensing error， the percentage of type error decreased from 0.005 2％ during Jun.-Dec. 2015 to 0.001 6％ during Jan.-Jun. 2016； that of number error decreased from 0.006 9％ to    0.001 6％； that of other error dropped to zero. During 2014-2016， the ratio of drug cost to treatment cost decreased gradually； those of inpatient were 26.62％， 24.91％， 24.36％， respectively； those of outpatient were 44.06％， 42.10％， 41.32％， respectively. Utilization rates of antibiotics in the inpatients decreased gradually， and were 44.82％， 44.14％， 43.91％， respectively. CONCLUSIONS： Information construction plays an important role on hospital pharmacy， can effectively improve work efficiency， reduces medication error and promotes rational drug use.