OBJECTIVE： To study the effects of Compound gastritis capsule on free acidity and protease activity of gastric juice in gastritis model rats and gastric emptying in gastric motility disorder model mice， and to provide reference for its development and utilization. METHODS： Totally 72 rats were randomly divided into normal group （n＝12） and model group （n＝60）. Model group was given 60％ ethanol combined with ursodeoxycholic acid to induce gastritis model of rats. After modeling， 55 rats were randomly divided into model group， ranitidine group （40 mg/kg） and Compound gastritis high-dose， medium-dose and low-dose groups （equivalent to 16， 8， 4 g/kg crude drug）， with 11 rats in each group. Rats of administration groups were given relevant drug intragastrically once a day. Normal group and model group were given constant volume of 0.5％ carboxymethylcellulose sodium （0.5％ CMC） solution for consecutive 28 d. After medication， free acidity and protease activity of gastric juice in gastritis model rats were determined； after HE staining， the pathological changes of gastric tissue were observed and the inflammatory score was observed. Totally 60 mice were randomly divided into normal group， model group， domperidone group （50 mg/kg）， Compound gastritis capsule high-dose， medium-dose and low-dose groups （equivalent to 20， 10， 5 g/kg crude drug）， with 10 mice in each group. Administration groups were given relevant medicine liquid intragastrically， and mice of normal group and model group were given constant volume of 0.5％ CMC solution intragastrically. 50 min after last medication， except for normal group， other groups were given atropine 3 mg/kg intraperitoneally to induce gastric motility disorder model. The residual rate of drug in the stomach of mice was determined 20 min after modeling. RESULTS： Compared with normol group，the free acidity and protease activity of gastric juice in rats in model group were increased significantly （P＜0.05），and the epithelial cells in the gastric mucosa were in disorder， a large number of inflammatory cells were infiltrated， the score of inflammation was increased significantly （P＜0.05）； the residual rate of drug in the stomach of mice in model group was increased significantly （P＜0.05）. Compared with model group， the free acidity and protease activity of gastric juice in rats in in ranitidine group and Compound gastritis capsule high-dose group was significantly  decreased （P＜0.05）， the histopathological injury of stomach was obviously reduced and the score of inflammation was significantly decreased （P＜0.05）； the residual rate in the stomach of mice in domperidone group and Compound gastritis capsule high-dose group was significantly decreased （P＜0.05）. CONCLUSIONS： Compound gastritis capsule can improve the free acidity and protease activity of gastric juice in gastritis model rat and improve the pathological changes of gastric tissue， and can promote the gastric emptying of the gastric motility disorder model mice.