OBJECTIVE： To establish a method for the simultaneous determination of galangin， galangin-3-methyl ether， bisdemethoxycurcumin， demethoxycurcumin and curcumin in mongolian medicine Xieriga-4. METHODS： HPLC method was adopted. The determination was performed on Elite C18 column with mobile phase consisted of 0.5％ phosphoric acid-acetonitrile （gradient elution） at the flow rate of 0.6 mL/min. The detection wavelengths were set at 235 nm （galangin， galangin-3-methyl ether） and 420 nm （bisdemethoxycurcumin， demethoxycurcumin and curcumin）. The column temperature was set at 25 ℃， and sample size was 10 μL. RESULTS： The linear range of galangin， galangin-3-methyl ether， bisdemethoxycurcumin， demethoxycurcumin and curcumin were 0.047 2-0.472 0 μg（r＝0.999 9）， 0.104 0-1.040 0 μg（r＝0.999 9）， 0.030 4-0.304 0 μg（r＝0.999 9），0.039 2-0.392 0 μg（r＝0.999 8）， 0.232 0-2.320 0 μg（r＝0.999 7）， respectively. The limits of quantitation were 11.41， 12.73， 4.92， 5.29， 5.39 ng； the limits of detection were 3.41， 3.72， 1.46， 1.59， 1.62 ng， respectively， respectively. RSDs of precision， stability and repeatability tests were all lower than 3％. The recovery rates were 97.24％-102.93％（RSD＝2.01％，n＝6）， 95.10％-101.50％（RSD＝2.34％，n＝6）， 95.23％-97.61％（RSD＝0.97％，n＝6）， 97.10％-100.65％（RSD＝1.24％，n＝6）， 98.69％-101.15％（RSD＝0.99％，n＝6）， respectively. CONCLUSIONS： The method is simple， accurate and reproducible. It can be used for simultaneous determination of galangin， galangin-3-methyl ether， bisdemethoxycurcumin， demethoxycurcumin and curcumin in mongolian medicine Xieriga-4.