OBJECTIVE： To promote the informatization of adverse drug event （ADE） management in outpatient pharmacy so as to reduce the risk of drug use. METHODS： From the aspect of the construction of two information platforms as problematic prescription management and ADR monitoring record and report， the practice of the informatization of ADE management in outpatient pharmacy of our hospital was introduced； the effects of information management were evaluated by real-time online record for the number of dispensing error and ADE and the number of ADR reported by outpatient pharmacists. RESULTS： The application of ADE management module for outpatient pharmacy developed by our hospital realized the following functions as real-time online record of “suspected prescription”， problematic prescription inquiry and summary， ADE report without delay， electronic ADR monitoring and reporting. 148 times of dispensing internal errors during Apr.-Jun. 2017 （accounting for 0.035％ of total prescription） and 15 ADEs during Jun. 2016-Jun. 2017 （accounting for 0.008‰ of total prescription） were recorded in outpatient pharmacy of our hospital. There were 82 ADR cases reported by outpatient physicians using user-friendly electronic ADR monitoring and reporting （accounting for 36.94％ of total ADR）. CONCLUSIONS： The construction of informatization promotes timely record of related error and adverse events， targeted management and ADR reporting and reduces the risk of drug use.