OBJECTIVE： To investigate and analyze the situation of measurement method for antimicrobial resistance （AMR） burden research， in order to provide methodology literature support for conducting AMR burden research in China. METHODS： Retrieved from PubMed， ProQuest Health & Medical Complete， Springer datebase， related researches were summarized， and foreign calculation method of resistance burden of commonly used antimicrobial and matters of attention were analyzed. RESULTS & CONCLUSIONS： AMR burden is usually evaluated using indicators like the number of resistant incidents， deaths due to AMR， excess length of stay and economic burden of AMR. The issues needed to be considered during calculating the burden included the perspective， definition of the outcome indicator， controlling the length of stay before infection， selection of control group， adjustment for severity of illness， time point calculation， calculation of onset time of infection， definition of the cost and scale of the economic burden. Future studies needs to be focused on a social perspective to estimate the burden of AMR， so as to provide baseline data evidence for decision makers to further control the resistance.