OBJECTIVE： To investigate the in vitro dissolution behavior and in vivo pharmacokinetics of Cinacalcet hydrochloride tablets， and to evaluate its in vivo-in vitro correlation （IVIVC）. METHODS： HPLC method was adopted to determine the accumulative dissolution（Q） of Cinacalcet hydrochloride tablets in 8 kinds of medium [pH 1.2 hydrochloric acid solution， pH 2.0 hydrochloric acid solution， pH 4.5 acetate buffer solution， pH 6.8 phosphate buffer solution， water， artificial gastric fluid （SGF）， full belly artificial intestinal fluid （FeSSIF）， fasting artificial intestinal fluid （FaSSIF）]， and the dissolution curves were drawn. HPLC-MS method was used to determine the blood concentrations of Cinacalcet hydrochloride tablets. A total of 12 healthy male volunteers were selected and given single oral dose of Cinacalcet hydrochloride tablets 75 mg under the state of fasting or satiety （high-fat food）. The blood concentration of cinacalcet hydrochlorid was determined before medication （0 h） and 0.5， 1， 2， 3， 4， 6， 8， 12， 24 h after medication. Average blood concentration-time curves were drawn. The in vivo accumulative absorption percentage （F） of satiety group was calculated by using DAS 3.0 software. Linear regression of F with in vitro Q was carried out to analyze its IVIVC. RESULTS： There was great difference among dissolution curves of Cinacalcet hydrochloride tablets in 8 kinds of dissolution mediums. There were differences of AUC0→t， AUC0→∞ and cmax between fasting group and satiety group， with statistical significance （P＜0.05）， showing high-fat food had significant effect on in vivo pharmacokinetics. Correlation coefficient of in vivo F in satiety group with in vitro Q of the tablets in FeSSIF was highest （0.977 9）， manifesting good IVIVC （class A）. CONCLUSIONS： The in vitro dissolution behavior of Cinacalcet hydrochloride tablets in FeSSIF （paddle method，50 r/min） is well associated with its in vivo pharmacokinetics， which can be used for predicting in vivo dissolution and absorption of the tablets.