OBJECTIVE： To establish a method for the resolution of Amlodipine benzenesulfonate racemates. METHODS： The chiral metal-organic frameworks [Zn2（D-Cam）2（4，4′ -bpy）]n （called Zn-MOF for short） were synthetized， and X ray powder  diffraction characterization was also performed. Chiral Zn-MOF was mixed with GF254 silica gel to prepare TLC solid phase and separate Amlodipine benzenesulfonate racemates. Using specific shift value and resolution degree of 2 enantiomers as index， resolution condition （composition and proportion of developing agent， amount of chiral Zn-MOF） were optimized and reproducibility test of method was also conducted. RESULTS： Chiral Zn-MOF material was successfully synthesized and confirmed after characterization. The optimal resolution condition was as follows as 0.10 g chiral Zn-MOF mixed with 1.5 g GF254 silica gel TLC plate， acetonitrile-butanol as developing agent （30 ∶ 70， V/V）. Under the condition， Amlodipine benzenesulfonate racemates was separated effectively； obtained spots were uniform in size with specific shift value＞0.27 and resolution rate of 2 （RSD＝3.8％， n＝3）. CONCLUSIONS： The stationary phase of TLC which is prepared by chiral Zn-MOF shows excellent chiral recognition， and resolution method is simple in operation. The result is intuitionistic， accurate and reproducible. The method is suitable for the chiral resolution of Amlodipine benzenesulfonate racemates.