OBJECTIVE： To observe therapeutic efficacy and safety of metoprolol combined with Shensong yangxin capsule in the treatment of ventricular premature beat.  METHODS： A total of 104 patients with ventricular premature beat during Jan. 2016-Jan. 2017 were analyzed retrospectively， and they were divided into control group （52 cases） and observation group （52 cases） according to medication plan. Control group was given Metoprolol tartrate tablet 25 mg orally， 3 times a day. Observation group was given Shensong yangxin capsule 1.2 g orally， 3 times a day， on the basis of control group. Both groups were treated for consecutive 28 d. Clinical efficacies of 2 groups were observed. The electrocardiogram P-R interval and Q-T interval， 24 h premature beat times， heart rate， the occurrence of palpitation before and after treatment and ADR were observed. RESULTS： Total response rate of observation group （92.30％） was significantly higher than that of control group （76.92％）， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in electrocardiogram P-R interval and Q-T interval， 24 h premature beat times， heart rate or palpitation times between 2 groups （P＞0.05）. After treatment， electrocardiogram P-R interval and Q-T interval of 2 groups were significantly higher than before treatment， and the observation group was significantly higher than the control group. 24 h premature beat times， palpitation times of 2 groups and heart rate of control group were significantly lower than before treatment； and 24 h premature beat times， palpitation times of the observation group was significantly lower than the control group， with statistical significance （P＜0.05）； there was no statistical significance in heart rate of observation group before and after treatment （P＞0.05）. There was no statistical significance in the total incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： For ventricular premature beat， metoprolol combined with Shensong yangxin capsule show significant therapeutic efficacy， can reduce the times of premature beat and improve patients’electrocardiogram without increasing the occurrence of ADR.