OBJECTIVE： To investigate the research hotspots of TCM safety and their relationship， so as to promote the improvement of TCM quality， TCM safety management and further research of TCM safety. METHODS： The word frequency analysis was used to study the frequency of keywords and thematic words related to TCM safety， quality and risk in literatures with the help of SATI 3.2 and Ucinet 6 statistical software. The co-occurrence analysis of high frequency keywords was conducted， and visual network graph of high frequency keywords was drawn on the basis of co-occurrence matrix. The network general characteristics of keywords were analyzed in respects of network density， concentration degree and small-world effect. The network individual characteristics of keywords were analyzed in respects of node centrality， betweenness centrality and closeness centrality， so as to discuss the research thematic hotspots and relevance. RESULTS & CONCLUSIONS： “TCM decoction piece”“processing”“TCM quality”“quality management” were main issues and key points of TCM safety research； TCM decoction piece was the most important field， the problems of which mainly reflected in TCM processing. The method and technology of TCM processing influenced TCM safety significantly. It is suggested to establish view of quality， improve the level of TCM safety by means of quality management， quality standard construction and quality control， reduce the risk of TCM safety， improve TCM quality and fully play the role of standard and standardization of Chinese Pharmacopoeia.