OBJECTIVE： To observe the clinical efficacy and safety of Zidan yinxie granules combined with Acitretin capsule and Compound flumetasone ointment in the treatment of psoriasis vulgaris. METHODS： A total of 97 patients with psoriasis vulgaris were divided into control group （48 cases） and observation group （49 cases） according to number random method. Control group was given Acitretin capsule 10 mg， tid， for consecutive 8 weeks， and then 10 mg， bid， for consecutive 4 weeks and Compound flumetasone ointment for external use， bid. Observation group was given Zidan yinxie granule 4 g， tid， on the basis of control group. Treatment courses of 2 groups lasted for 12 weeks. Clinical efficacy was observed in 2 groups. Psoriasis area and severity index （PASI） score， VAS score， dermatology life quality index （DLQI） score， the expression of neutrophil elastase （NE）， Trappin-2 and placental calcadin （P-cad） in serum and tissue fluid of skin lesion were observed before and after treatment.  Recurrence followed up for 6 months in total effective patients and the occurrence of ADR were observed. RESULTS： Two patients of observation group withdrew from the study， and 47 patients completed the study； three patients of control group withdrew from the study， and 45 patients completed the study. Total response rate of observation group was 97.87％， which was significantly higher than 84.44％ of control group， with statistical significance （P＜0.05）. After treatment， PASI， VAS and DLQI scores， the content of NE， Trappin-2 and P-cad in serum and tissue liquid of skin lesion were significantly lower than before treatment； the observation group was significantly lower than the control group. After 6-month follow-up， recurrence rate of total effective patients in observation group （28.26％） was significantly lower than control group （47.36％）， and average recurrence time of observation group [（17.91±3.10） weeks] was longer than that of control group [（9.80±3.41） weeks]， with statistical significance （P＜0.05）. There was no statistical significance in the total incidence of ADR between 2 groups（P＞0.05）.  CONCLUSIONS： Zidan yinxie granules combined with Acitretion capsule and compound flumetasone ointment show clinical efficacy in the treatment of psoriasis vulgaris by lowering the expression of NE， Trappin-2 and P-cad in serum and tissue liquid of skin lesion with good safety.