OBJECTIVE： To investigate the effects of Kangfuxin solution combined with Chuangyangling and gelatin sponge on dry socket disease in patients with type 2 diabetes mellitus after the extraction of impacted teeth. METHODS： A total of 85 patients with impacted teeth and type 2 diabetes mellitus during Jan. 2016-Jan. 2017 were divided into group A （29 cases）， B （25 cases）， C （31 cases） according to random number table. All patients were treated with turbine drill method； in group A， Kangfuxin solution+Absorbable gelatin sponge was used to fill the wound site； in group B， Chuangyangling+compound preparation of Kangfuxin solution and gelatin sponge were used to fill the wound site； in group C， the wounds were filled with gauze but without any drugs. All patients received routine anti-infective treatment after surgery for 5-7 d. The time of impacted teeth extraction was observed in 3 groups； granulation tissue coverage integrity rate of tooth socket and the incidence of dry socket disease 7 d after surgery， the incidence of other postoperative complications， treatment cost， satisfaction scores were also comparod. RESULTS： There was no statistical significance in the time of impacted teeth extraction or treatment cost among 3 groups （P＞0.05）. Seven days after surgery， granulation tissue coverage integrity of tooth socket and satisfaction scores were in descending order： group B＞group A＞group C； the incidence of dry sockets were in ascending order： group B＜group A＜group C， with statistical significance （P＜0.05）. The incidence of other postoperative complications as bleeding， pain， swelling， limitation of mouth opening in group A and B were significantly lower than group C， with statistical significance （P＜0.05）. There were no statistical significance between group A and B （P＞0.05）. CONCLUSIONS： Kangfuxin solution combined with Chuangyangling and gelatin sponge can effectively increase granulation tissue coverage integrity of tooth socket， and reduce the incidence of dry socket disease and other postoperative complications in patients with type 2 diabetes mellitus， but do not increase economic burden of patients and obtain high patient satisfaction.