OBJECTIVE： To explore the management mode of key monitored drugs in hospital and to improve their rational use. METHODS： The pharmaceutical administration mode of key monitored drugs in our hospital was interpreted in respects of nontrol plan， control measures and control effect （using types and ranking of key monitored drugs among top 10 drugs in the list of consumption sum， ratio of consumption sum of key monitored drugs in total consumption sum， consumption sum per capita of key monitored drugs in the inpatients as indexes）. RESULTS： Our hospital confirmed and implemented control plans as control target and control index by formulating key monitored drug list. Key monitored drug control was included in performance assessment management， procurement source management， supernormal early warning management， etc. The key monitored drug control was implemented from May 2016， up to May 2017， key monitored drugs ranked and decreased in number from the top 10 drugs in the list of consumption sum. The ratio of consumption sum of key monitored drugs in total consumption sum and consumption sum per capita of key monitored drugs in the inpatients decreased from 34.33％ and 2 318.98 yuan before control （Jan. 2016-Apr. 2016） to 21.72％ and 1 209.31 yuan in May 2017 （decreasing by 36.73％， 47.85％）. CONCLUSIONS： Key monitored drug control obtains significant achievement in our hospital， can effectively promotes rational use of key monitored drug， saves medical insurance costs and reduces the economic burden of patients.