OBJECTIVE： To study risk factors for carbapenem-resistant Acinetobacter baumannii （CRAB） infection， and to provide reference for its clinical prevention. METHODS： In retrospective study， 302 A. baumannii （AB） infection patients were collected from our hospital during Dec. 2012 to Jun. 2017. According to the results of drug sensitivity test， those patients were divided into CRAB group （116 cases） and non-CRAB group （186 cases）. Risk factors for CRAB infection were analyzed by using univariate analysis. Multivariate Logistic regression analysis was performed for variables with significant difference between 2 groups. RESULTS： Univariate analysis showed that the factors of significant difference in 2 groups including patients suffering from septic shock （P＝0.003）， sepsis （P＝0.000）， combined with other infection （P＝0.006）， diabetes （P＝0.029）， malignant tumors （P＝0.036）， patients suffering from infection of other site except for pulmonary infection， intraabdominal infection and skin infection （P＝0.009） before AB isolation， patients given carbapenems （P＝0.002） and antifungal drugs 28 d before AB isolation （P＝0.002）. Multivariate Logistic regression analysis showed that the factors of significant difference in 2 groups including patients suffering from sepsis （P＝0.033） or diabetes （P＝0.011） before AB isolation. CONCLUSIONS： Independent risk factors for CRAB infection include patients suffer from sepsis or diabetes before AB isolation.