OBJECTIVE： To investigate effects of different doses of nalbuphine combined with propofol on anesthesia and analgesic effect of patients underwent hysteroscopic surgery. METHODS： A total of 120 inpatients undergoing painless hysteroscopic surgery were selected as research objects during Feb.-Nov. 2016. They were divided into group P， N1， N2， N3 according to random number table， with 30 cases in each group. Routine preoperative preparation was conducted in 4 groups. Group N1， N2， N3 were given Nalbuphine hydrochloride injection 0.05， 0.10， 0.15 mg/kg slowly， iv， within 1-2 min. After 3 min of injection， 4 groups were given 2％ Lidocaine hydrochloride injection 2 mL， iv+ Propofol injection 1 mg/kg，iv（40 mg/10 s）， and then injected with Propofol injection （10 mg/10 s） slowly until the patient’s eyelash reflex disappeared and no response was aroused. During surgery， Propofol injection was infused with micro pump at 6 mg/（kg·h） to maintain anesthesia until the end of operation. The levels of hemodynamic parameters （SBP， DBP， HR） and SpO2 of 4 groups were observed after admission to operating room （T0）， before propofol infusion （T1）， immediately after propofol infusion （T2）， during uterine cervical distension （T3）， at the end of surgery （T4） and during anesthesia recovery （T5）， respectively. The induction dose， maintenance dose， total dose， total dosing time and unit time dose of propofol， anesthesia recovery time and NRS scores after anesthesia recovery of patients were also observed in 4 groups. The occurrence of ADR was recorded during operation and anesthesia recovery. RESULTS： There was no statistical significance in maintenance dose and total dosing time of propofol， the incidence of body motion reaction， hypotension， sinus bradycardia， nausea and vomiting among 4 groups （P＞0.05）. At T0， there was no statistical significance in hemodynamic parameters or SpO2 among 4 groups （P＞0.05）. Compared to T0， SBP of 4 groups were decreased significantly at T2， that of group N1 was decreased significantly at T3-T4， and that of group N2 was decreased significantly at T3， with statistical significance （P＜0.05）. DBP of 4 groups were decreased significantly at T2， that of group N1 was decreased significantly at T3-T5， and that of group N2 was decreased significantly at T3， with statistical significance （P＜0.05）. HR of group P was decreased significantly at T3， and that of group N3 was decreased significantly at T5， with statistical significance （P＜0.05）. SpO2 of 4 groups were decreased significantly at T2， and that of group N3 was decreased significantly at T3， with statistical significance （P＜0.05）. SpO2 of group N3 at T1 was significantly lower than that of group P； at T2， it was significantly lower than other groups； at T3， it was significantly lower than group P and N1， with statistical significance （P＜0.05）. Compared to group P， induction dose， total dose and unit time dose of propofol， NRS scores of patients were significantly decreased in group N2 and N3； the anesthesia recovery time of group N1， N2， N3 were shortened significantly， with statistical significance （P＜0.05）. Compared with group N1， induction dose， total dose and unit time dose of propofol， NRS scores were significantly decreased in group N2 and N3， and anesthesia recovery time of them were shortened significantly， with statistical significance （P＜0.05）. Compared to group N2， induction dose and total dose of propofol were decreased signigficantly in group N3， with statistical significance （P＜0.05）. Compared with group P， the incidence of dizziness was increased significantly in group N3； compared with group P， N1， N2， the incidence of hypoxemia was increased significantly in group N3， with statistical significance （P＜0.05）. CONCLUSIONS： Nalbuphine 0.10 mg/kg combined with propofol for hysteroscopic surgery can achieve good anesthesia and analgesic effect with high safety.