OBJECTIVE: To establish the quality standard of Tibetan medicine Myricaria germanica. METHODS: M. germanica was identified in respects of properties, microscopic characteristics and TLC. The contents of moisture, ash and extract were determined. HPLC method was adopted for content determination of gallic acid. The determination was performed on Diamonsil C18 column with mobile phase consisted of acetonitrile -0.1% phosphoric acid solution(5 ∶ 95,V/V) at the flow rate of 1.0 mL/min. The detection wavlengths were set at 270 nm. The column temperature was 30 ℃ and the sample size was 10 μL. RESULTS: M. germanica was cylindrical in shape, and there were many narrow strip alternate leaflets, which were brittle, easily broken, weak in smell, mild in flavor. Cork cell surface and lower epidermal cell surface showed polygon; most of xylon were bunched; there were many clusters of calcium oxalate. TLC spots were clear and well-separated. The contents of moisture, total ash, acid-insoluble ash, water-soluble extract and ethanol were 6.83%-8.12%,4.01%-5.01%,1.06%-1.98%,17.91%-22.65%, 11.29%-15.51%. The linear range of gallic acid were 3.13-50 μg/mL(r=0.999 7); RSDs of precision, stability and reproducibility tests were lower than 1.0%; the recoveries were 94.0%-100.8%(RSD=2.27%,n=9). CONCLUSIONS: Established standard can be used for quality evaluation of Tibetan medicine M. germanica.