OBJECTIVE： To establish the method for content determination of 12 trace elements （Cu， Mn， Mg， Cd， Zn， Fe， Ba， Se， Pb， As， Cr， Ni） in Shiquan dabu pills， and to provide reference for further improvement of its quality control. METHODS： ICP-OES was adopted to detect. Microwave digestion was used for sample pretreatment with digestion power of 800 W； digestion process included heating to 120 ℃ keeping for 3 min， heating to 160 ℃ keeping for 5 min， and finally heating to 180 ℃ keeping for 20 min.  PF power was 1 150 W， and pump speed was 50 r/min； the flow rate of atomizing gas was 0.5        L/min， and that of plasma gas was 12.0 L/min， detection wavelength of 182.205-455.403 nm. RESULTS： Results of 12 elements determination were all within standard range according to national standard substance sampling determination. The liner ranges of Cu， Mn， Mg， Cd， Zn， Fe， Ba， As， Cr and Ni were 0.2-2.0 mg/L， those of Se and Pb were 0.4-4.0 mg/L （r≥0.999 5）. The detection limits ranged 0.1-8.5 μg/L， and limits of quantitation were 0.3-28.3 μg/L. RSDs of precision tests were all lower than 1.00％ （n＝6）. The average recovery rates were 88.5％-99.0％ （RSD were 1.7％-4.9％， n＝6）. CONCLUSIONS： The method is rapid， simple and sensitive， and it can be used for content determination of 12 trace elements in Shiquan dabu pills.