OBJECTIVE： To investigate the effects of doxorubicin perfusion therapy on therapeutic efficacy and related indexes in patients with superficial bladder cancer underwent transurethral resection of bladder tumor （TURBT）. METHODS： Medical records of 96 patients with superficial bladder cancer were analyzed retrospectively and divided into observation group and control group according to drug use， with 48 cases in each group. Observation group was given perfusion therapy of 0.9％ Sodium choride solution 40 mL containing 20 mg doxorubicin 7 d after surgery. Control group was given TURBT combined with equal amount of 0.9％ Sodium chloride solution. Both groups received treatment for consecutive 10 months， once a week in first 8 weeks， later once a month. The recurrence rate and disease progression of 2 groups were observed and compared， and the levels of sICAM-1 and sVCAM-1， the levels of tumor marker DKK1 and VEGF were observed before and after treatment. The occurrence of ADR was recorded. RESULTS： After 24 months of treatment， remission rate and control rate of observation group were significantly higher than control group， with statistical significance （P＜0.05）. There was no statistical significance in the progressive survival rate between 2 groups （P＞0.05）. Before treatment， there was no statistical significance in the levels of sICAM-1、sVCAM-1、DKK1 and VEGF between 2 groups （P＞0.05）； after treatment， the levels of sICAM-1、sVCAM-1、DKK1 and VEGF in 2 groups were significantly lower than before treatment， the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. The recurrence rate， the incidence of frequent/urgent urination， hematuria and dysuria in observation group after treatment were significantly lower than control group， with statistical significance （P＜0.05）.CONCLUSIONS： For patients with superficial bladder cancer underwent TURBT， doxorubicin perfusion therapy can significantly reduce recurrence rate， relieve tumor deterioration and reduce tumor activity with good safety.