OBJECTIVE： To investigate therapeutic efficacy and safety of the use of Kubai oil and Cuyu oil by stages on wound healing after perianal abscess operation. METHODS： A total of 125 observation objects selected from Chengdu Third People’s Hospital during Jan. 2014-Jan. 2016 were randomly divided into control group （60 cases） and observation group （65 cases）. Both groups received perianal abscess incision drainage or thread-drawing drainage. Control group was additionally given gentamicin gauze for dressing and other treatments after surgery based on routine treatment. Observation group was given Kubai oil gauze for dreassing in wound inflammation period， Cuyu oil gauze for dressing in granulation growth period and epithelial growth period. After 4 weeks of treatment， therapeutic efficacy， wound healing， wound pain， wound secretion and the growth of granulation tissue were compared between 2 groups. The occurrence of ADR was also recorded. RESULTS： The cure rate of observation group reached 80.0％， which was significantly higher than 63.3％ of control group （P＜0.05）； the reduction rate of wound area was significantly higher than control group， while the carrion shedding time and wound healing time were significantly lower than control group （P＜0.01 or P＜0.05）. The wound pain score in 2nd， 4th week， the wound secretion score and granulation tissue growth score in 1st， 2nd， 4th week after operation were significantly lower than control group （P＜0.01 or P＜0.05）. No significant ADR was found in 2 groups. CONCLUSIONS： For the patients underwent perianal abscess operation， the use of Kubai oil and Cuyu oil by stages can effectively improve therapeutic efficacy and wound healing， and relieve postoperative pain with good safety.