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LI Zhijin; LI Jing; ZHANG Yue; YANG Zanzhang

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更新时间：2023-03-01

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- China Pharmacy Vol. 28, Issue 34, (2017)
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LI Zhijin, LI Jing, ZHANG Yue, et al. [J]. China Pharmacy 28(34).(2017)
DOI：

LI Zhijin, LI Jing, ZHANG Yue, et al. [J]. China Pharmacy 28(34).(2017) DOI：

摘要

目的：研究缬沙坦胶囊灌胃给药后在兔眼组织的分布规律。方法：取兔3只（6只眼），ig缬沙坦溶液，每次7.5 mg，每日2次，连用6 d。于末次给药后1 h处死兔，采集角膜、虹膜、房水、晶状体、玻璃体液、视网膜组织，采用高效液相色谱法测定各组织中缬沙坦的含量。结果：缬沙坦在视网膜、虹膜、角膜、房水、玻璃体液、晶状体中的含量依次为（4.274±1.75）、（2.233±0.72）、（0.871±0.66）、（0.713±0.49）、（0.177±0.07）、（0.083±0.06） μg/g。结论：连续多次给药后缬沙坦在兔眼内各组织中分布不均匀，以视网膜中的含量为最高，虹膜次之，晶状体、玻璃体液中的含量最低。

Abstract

OBJECTIVE： To study the distribution law of Valsartan capsules in the ocular tissue of rabbit eyes after intragastrical administration. METHODS： 3 rabbits （6 eyes） were intragastrically administrated Valsartan solution， 7.5 mg every time， twice a day， for 6 d. Rabbits were executed after last administration， and the cornea， iris， aqueous humor， lens， vitreous and retina tissues were collected. HPLC was used to determine the content of valsartan in each tissue. RESULTS： Content of valsartan in retina， iris， cornea， aqueous humor， vitreous and lens were （4.274±1.75），（2.233±0.72），（0.871±0.66），（0.713±0.49），（0.177±0.07），（0.083±0.06） μg/g， respectively. CONCLUSIONS： After multiple administrations， valsartan distributes unevenly in each tissue of eyes， showing highest distribution content in retina， followed by iris， and lowest content in lens and vitreous.

关键词

缬沙坦高效液相色谱法眼组织兔分布

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ValsartanHPLCOcular tissueRabbitDistribution

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