OBJECTIVE： To investigate clinical efficacy and safety of vitamin D combined with azithromycin in the treatment of pneumonia in patients with type 2 diabetes and its effects on serum inflammation indexes. METHODS： A total of 68 patients with type 2 diabetes complicated with pneumonia selected from our hospital during May 2014-Sept. 2015 were divided into control group and trial group according to random number table， with 34 cases in each group. Both groups received insulin intensive hypoglycemic therapy. Control group was given Azithromycin for injection 10 mg/kg+0.9％ Sodium chloride injection 100 mL， ivgtt， qd， for consecutive 5 d， and then used Azithromycin dry suspension instead 10 mg/kg， po， qd， consecutive 3 d treatment and 4 d interval as a treatment course， for 2 cycles. Trial group was additionally given Vitamin D drops 800 U， po， qd， for consecutive 4 weeks， on the basis of control group. The clinical efficacies of 2 groups were observed， and serum inflammation indexes [interleukin-6 （IL-6）， C-reactive protein （CRP）， immunoglobulin G protein （IgG）] levels were also observed before and after treatment. The occurrence of ADR was recorded. RESULTS： Total response rate of trial group （91.18％） was significantly higher than that of control group （70.59％）， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in serum inflammation indexes as IL-6， CRP， IgG between 2 group （P＞0.05）. After treatment， IL-6 and CRP of 2 groups were decreased significantly， and the trial group was significantly lower than the control group； IgG of 2 groups were increased significantly， and the trial group was significantly higher than the control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Vitamin D combine with azithromycin in the treatment of pneumonia in patients with type 2 diabetes has a good clinical curative effect， helps to improve the levels of IL-6， CRP and IgG with good safety.