OBJECTIVE： To establish the method for simultaneous determination of liquiritin and glycyrrhizic acid in Fuzi lizhong pills （condensed pills）. METHODS： HPLC method was adopted. The determination was performed on WondaSil C18 column with mobile phase consisted of acetonitrile-0.05％ phosphate solution （gradient elution） at the flow rate of 1.0 mL/min. The detection wavelength was set at 237 nm， and column temperature was 35 ℃. The sample size was 10 μL. RESULTS： The linear range of liquiritin and glycyrrhizic acid were 9.68-96.8 μg/mL（r＝0.999 1）and 14.08-140.8 μg/mL（r＝0.999 2）. The limits of quantitation were 0.2， 0.3 μg/mL， and the limits of detection were 0.1， 0.01 μg/mL. RSDs of precision， stability and reproducibility tests were all lower than 2.0％. The average recoveries were 98.9％-101.2％（RSD＝0.62％，n＝9），98.6％-101.5％（RSD＝1.06％，n＝9）. CONCLUSIONS： The method is simple and accurate， and can be used for simultaneous determination of liquiritin and glycyrrhizic acid in Fuzi lizhong pills （condensed pills）.