OBJECTIVE： To study the improvement effect of geniposide on cognitive dysfunction in model rats with diabetes. METHODS： 50 rats were randomly divided into blank control group （distilled water）， model group （distilled water） and geniposide low-dose， medium-dose， high-dose groups （5， 10， 20 g/kg）， 10 in each group. Except for blank control group， rats in other 4 groups were fed with high-sugar and high-fat diet and injected streptozotocin to induce diabetes model. After modeling， rats in each group intragastrically administrated relevant medicines， once a day， for 8 weeks. After last administration， fasting blood glucose （FPG）， glycosylated hemoglobin （HbA1c） levels， escape latency period in Morris water maze test， and correct rate of behaviors in Y maze test of rats in each group were detected. RESULTS： Compared with blank control group， FPG， HbA1c levels of rats in model group were obviously increased， escape latency period was obviously prolonged， correct rate of behaviors in Y maze test was obviously decreased， with statistical significances （P＜0.05）. Compared with model group， above-mentioned indexes in geniposide groups were obviously improved （P＜0.05）， which were positively correlated with dose （P＜0.05）. CONCLUSIONS： Geniposide can effectively reduce blood glucose level of model rats with diabetes and improve their cognitive dysfunction.