OBJECTIVE： To optimize the flash extraction technology for Guizhi fuling capsule. METHODS： Using blade speed， liquid-solid ratio， extraction time as investigation factors， using the comprehensive evaluation values consisting of transfer rates of gallic acid， paeoniflorin， benzoic acid， cinnamic acid， benzoyl paeoniflorin， amygdalin as investigation index， single factor test was combined with Box-Behnken design-response surface method to optimize the flash extraction technology for Guizhi fuling capsule. Verification test was conducted and compared with conventional decoction extraction method （extracting twice， totally 240 min）. RESULTS： The optimal flash extraction technology for Guizhi fuling capsule was using water as extraction solvent with blade speed of 5 600 r/min and liquid-solid ratio of 10.5 ∶ 1， extracting for 60 s. The average comprehensive evaluation value of verification test was 85.40％ （n＝3）， with relative error of 0.15％ to the predicted value （85.55％）， higher than decoction extraction method （72.65％）. CONCLUSIONS： Optimized flash extraction technology for Guizhi fuling capsule is efficient and rapid.