OBJECTIVE： To investigate the effects of plasma exchange （PE） combined with intensive insulin glycemic control on related indexes of patients with HLP. METHODS： A total of 120 HLP patients were randomly divided into control group （60 cases） and observation group （60 cases）. Based on routine treatment， 2 groups were given PE treatment for 3 times+Low molecular weight heparin calcium for injection 5 000 U subcutaneously+Methylprednisolone sodium succinate for injection 40 mg intravenously+Calcium gluconate injection 2 g intravenously. Based on it， Insulin injection was pumped to random blood glucose ＜12 mmol/L with a micro-infusion pump in control group when random blood glucose concentration was equal to or more than 12 mmol/L. When random blood glucose of patients in observation group were higher than 8.3 mmol/L， Insulin injection was pumped with a micro-infusion pump for a week and random blood glucose concentration was maintained at 6.1-8.3 mmol/L. Plasma levels of triglyceride， PCT， WBC count， APACHEⅡ score， Balthazar CT score， length of hospitalization stay in ICU and the occurrence of ADR were observed in 2 groups before and after treatment. RESULTS： After treatment， plasma levels of triglyceride， amylase and PCT， WBC count， APACHEⅡ score and Balthazar CT score in 2 groups were significantly lower than before treatment， and the observation group was significantly lower than the control group， with statistical significance（P＜0.05）. Length of hospitalization stay in ICU observation group was significantly shorter than control group， with statistical significance（P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups（P＞0.05）. CONCLUSIONS： PE combined with intensive insulin glycemic control can effectively reduce the level of plasma triglyceride，relieve inflammatory reaction and improve prognosis without increasing the occurrence of ADR.