OBJECTIVE： To investigate the risk factors and clinical outcome for carbapenems-resistant Pseudomonas aeruginosa （CRPA） infection， and to provide reference for the prevention and treatment of CRPA infection. METHODS： In retrospective investigation， medical records of CRPA and carbapenems-sensitive Pseudomonas aeruginosa （CSPA） infection were collected from our hospital during 2013-2016. CRPA infection risk factors were judged by single factor analysis. The relationship of CRPA risk factors and death was judged by multivariate Logistic regression analysis. RESULTS： A total of 556 cases of P. aeruginosa infection were collected， including 96 cases of CRPA injection， accounting for 17.3％. Multivariate Logistic regression analysis of related factors of CRPA infection showed that independent risk factors of CRPA infection included admission to ICU for more than 3 days before the isolation of P. aeruginosa [OR＝2.691， 95％CI （1.348，5.373），P＝0.005]， the use of third-generation or fourth-generation cephalosporin [OR＝0.386，95％CI （0.200，0.742），P＝0.004]， complicated with other pathogenic bacteria infection [OR＝1.892，95％CI （1.132，3.164），P＝0.015]， combined with 2 kinds of antibiotics or above [OR＝5.631，95％CI （2.556，12.407），P＝0.000]. Clinical outcome analysis， mortality rate of CRPA infection were 12.5％， significantly higher than CSPA infection （2.8％）， Logistic regression analysis， there is a correlation between death rate [OR＝5.003， 95％CI （1.975，12.675）， P＝0.001] and CRPA infection. CONCLUSIONS： For the prevention of CRPA nosocomial infection， it is necessary to reduce the time of ICU stay and rationally select antibiotics according to pathogenic bacteria so as to reduce the occurrence of CRPA infection.