OBJECTIVE： To study the clinical effects of curettage under hysteroscopy combined with estrogen and progesterone in preventing intrauterine adhesion after missed abortion. METHODS： A total of 120 patients receiving missed abortion selected from gynecology department of our hospital during Jun. 2014-Jun. 2016 were randomly divided into observation group （60 cases） and control group （60 cases） according to seguential coding. Observation group was given estradiol valerate 3 mg，qd， for 5 d in total， received curettage under hysteroscope， and was given Estradiol valerate tablet/Estradiol valerate cyproterone tablet one tablet，qd after surgery， for 21 d. Control group received routine curettage and didn’t take estrogen and progesterone during the perioperative period. The time of vaginal bleeding， endometrial thickness 14 d after surgery， the amout of vaginal bleeding with in 3 months after surgery， intrauterine adhesion， the occurrence of ADR were observed in 2 groups. RESULTS： In observation group， 57 cases completed the study except that 2 cases withdrew from the study due to the amount of vaginal bleeding as much as menstrual volume and 1 case withdrew from the study due to pregnancy tissue self-discharge. The duration of postoperative vaginal bleeding was （3.2±1.1） d in observation group and （5.4±1.9） d in control group. The endometrial thickness of observation group was （8.04±1.52） mm and that of control group was （5.27±2.36） mm； the incidence of intrauterine adhesion was 3.5％ in observation group （2/57） and 15％ in control group （9/60）. Above indexes of observation group were better than those of control group （P＜0.05）. CONCLUSIONS： Curettage under hysteroscope combined with estrogen and progesterone helps to reduce post-curettage vaginal bleeding， promote endometrial repair and prevent intrauterine adhesion so as to protect women’s reproductive ability.