OBJECTIVE： To provide reference for clinical use of toxic herbs and decoction pieces contained in Chinese Pharmacopoeia （2015 edition， part 1） （referred to Chinese Pharmacopoeia）. METHODS： The contents in “taste and meridian” “usage and dosage” “note” for herbs and decoction pieces contained in Chinese Pharmacopoeia were summed up. Varieties and toxicity grading of toxic herbs and decoction pieces and precautions for clinical use were summarized. It was compared with Shennong Bencaojing and Zhongyao Dacidian， and examined whether there were differences in the presence or absence of toxicity and toxicity grading in Chinese Pharmacopoeia. RESULTS： Chinese Pharmacopoeia contained 83 kinds of toxic herbs and decoction pieces， in which， 10 had great toxicity， 42 had general toxicity and 31 had small toxicity. There were restrictive provisions for the use of toxic TCM， in which， 30 were forbidden for pregnant women， 1 should be contraindicated for pregnant women， 16 should be avoided for pregnant women，3 should be avoided for athletes， 6 can’t be taken orally， 8 should be avoided when taken orally， 3 were inappropriate for using with crude drugs， 5 were used by pills， and 13 were often used by pills. There were 30 toxic TCM in Chinese Pharmacopoeia， which were recorded in Shennong Bencaojing as well. 3 were recorded as toxic drugs in Chinese Pharmacopoeia while non-toxic drugs in Shennong Bencaojing， 14 had the same toxicity grading and 13 had not. And there were 80 toxic TCM in Chinese Pharmacopoeia， which were recorded in Zhongyao Dacidian as well. 6 were recorded as toxic drugs in Chinese Pharmacopoeia while non-toxic drugs in Zhongyao Dacidian， 60 had the same toxicity grading and 14 had not. CONCLUSIONS： Chinese Pharmacopoeia shows differences with Shennong Bencaojing and Zhongyao Dacidian in the presence or absence of TCM toxicity and toxicity grading. It is necessary to set up unified grading standards for toxic TCM to avoid doubts in clinical use.